Justin Shenk

Lefty guitarist Duane Allman has one of the best sounds and styles in classic rock, but he played right handed. I think there is a significant boost to the left hand if one is left handed.

Also, Duane was in fact left-handed, despite playing the guitar as if right handed. This added strength in his fretting hand gave him a greater degree of control when bending notes or adding vibrato, plus it meant that his picking hand was not quite as strong, seeming to give him a very light touch. Listen to the version of Dreams from the debut album for an example of his extraordinary control over slow bends and slow vibrato. This also gave him added strength and dexterity with his pinky on his fretting hand.

via Duane Allman (Hotguitarist.com)